SOLDESAM

Pharmacological action

Soldesam drug & pharmaceuticals active ingredients names and forms
Soldesam drug & pharmaceuticals active ingredients names and forms

Soldesam is a glucocorticosteroid. This drug inhibits the function of white blood cells and tissue macrophages. Soldesam restricts the migration of leukocytes in the area of inflammation. The drug impairs the ability of macrophages to phagocytosis and formation of interleukin-1. Capillary permeability caused by histamine release is reduced. The drug inhibits the activity of fibroblasts and collagen formation. Soldesam drug & pharmaceuticals active ingredients names and forms, pharmaceutical companies. Soldesam indications and usages, prices, online pharmacy health products information.

Selling paltesam inhibits the activity of phospholipase A2, which leads to suppression of the synthesis of prostaglandins and leukotrienes.

When directly acting on blood vessels, the drug has a vasoconstrictor effect.

Selling in vessels has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats.

In high doses, the impregnation may increase the excitability of brain tissue and contribute to lowering the threshold of seizure readiness.

When used systemically, Soldesam therapeutic activity is due to anti-inflammatory, anti-allergic, immunosuppressive and antiproliferative effects.

When used externally and topically, the therapeutic activity of Soldesam is due to anti-inflammatory, anti-allergic and anti-exudative action.

Pharmacokinetics

Plasma protein binding is 60-70%. This drug penetrates the histohematic barriers. In small amounts it is excreted in breast milk. It is metabolized in the liver. T1/2 is 2-3 hours. The drug is excreted by the kidneys.

When used topically in ophthalmology, it is absorbed through the cornea with intact epithelium in the moist anterior chamber. With inflammation of ocular tissues or damage to the mucous membrane and the rate of absorption of the cornea, the rate of absorption of the shell increases significantly.

Why is Soldsam prescribed?

For oral pplication: Birmer’s disease; acute and subacute thyroiditis, hypothyroidism, progressive ophthalmopathy associated with thyrotoxicosis; bronchial asthma; rheumatoid arthritis in the acute phase; ulcerative colitis; connective tissue disease; autoimmune hemolytic anemia, thrombocytopenia, hematopoiesis aplasia and hypoplasia, agranulocytosis, serum disease; acute erythroderma, pemphigus, acute eczema (early treatment); malignant tumor (as palliative therapy); congenital adrenogenital syndrome; cerebral edema (usually after prior parenteral corticosteroid administration).

For parenteral pplication: Shock of various origins; cerebral edema (in brain tumors, head trauma, neurosurgery, brain hemorrhage, encephalitis, meningitis, radiation injury); asthmatic condition; severe allergic reactions (angioedema, bronchospasm, dermatosis, acute anaphylactic reaction to medications, transfusion serum, pyrogenic reactions) acute hemolytic anemia, thrombocytopenia, acute lymphoblastic leukemia, agranulocytosis; severe infectious diseases (in combination with antibiotics); acute adrenal insufficiency, acute croup; Arthropathy (scapulo-rumeral periarthritis, epicondylitis, styloiditis, bursitis, tenosynovitis, compression neuropathy, osteochondrosis, arthritis of various etiologies, osteoarthritis).

For use in ophthalmic practice: non-purulent and allergic conjunctivitis, keratitis, keratoconjunctivitis without epithelial damage, iritis, iridocyclitis, blepharoconjunctivitis, blepharitis, episcleritis, scleritis, inflammation of eye injuries and operations, sympathetic ophthalmia.

Dosage and application

Soldesam drug & pharmaceuticals active ingredients names and forms
Soldesam drug & pharmaceuticals active ingredients names and forms

The dosing regimen is individual. Ordinarily, in severe disease, up to 10-15 mg/day is prescribed at the beginning of treatment, the maintenance dose may be 2-4.5 mg/day or more. The daily dose is divided into 2-3 doses. In low doses, Sales is taken 1 time in the morning.

For parenteral administration, the drug is administered intravenously by slow bolus or infusion (acute and emergency conditions); IM; periarticular and intraarticular administration is also possible. Between 4 and 20 mg of SPS can be taken 3 to 4 times a day. The duration of parenteral administration is usually 3-4 days, then switch to oral maintenance therapy. In the acute period in various diseases and in the early stages of treatment shell be used in higher doses. Once the effect is achieved, the dose is reduced for several days until a maintenance dose is reached or until treatment is discontinued.

When used in ophthalmology for acute diseases, the drug is instilled into the conjunctival sac with 1-2 drops every 1-2 hours, then with decreasing inflammation every 4-6 hours. Duration of treatment is from 1-2 days to several weeks depending on the clinical course of the disease.

Side effects of use, adverse reactions

Endocrine system: impaired glucose tolerance, steroid diabetes mellitus or manifestation of latent diabetes mellitus, suppressed adrenal function, Itenko-Cushing syndrome, delayed sexual development in children.

Metabolism: increased calcium excretion, hypocalcemia, weight gain, negative nitrogen balance (increased protein breakdown), increased sweating, hypernatremia, hypokalemia.

CNS: delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia, increased intracranial pressure, nervousness or anxiety, insomnia, dizziness, vertigo, pseudotumor cerebri, headache, convulsions.

Cardiovascular system: arrhythmia, bradycardia (up to cardiac arrest); development (in predisposed patients) or increased severity of chronic heart failure, ECG changes typical of hypokalemia, increased blood pressure, hypercoagulation, thrombosis. In patients with acute and subacute myocardial infarction – spread of necrosis, delayed formation of scar tissue, which may lead to rupture of the heart muscle; in intracranial administration – nasal bleeding.

Digestive organs: nausea, vomiting, pancreatitis, steroid ulcers of the stomach and duodenum, erosive esophagitis, bleeding and perforation of the gastrointestinal tract, increased or decreased appetite, flatulence, hiccups; rarely – increased activity of liver transaminases and alkaline phosphatase.

Organs of the senses: posterior subcapsular cataract, increased intraocular pressure with possible damage to the optic nerve, tendency to develop secondary bacterial, fungal or viral eye infections, trophic changes of the cornea, exophthalmia.

Musculoskeletal system: growth retardation and ossification processes in children (premature closure of epiphyseal growth zones), osteoporosis (very rarely – pathological bone fractures, aseptic necrosis of the head of the humerus and femur), muscle tendon rupture, steroid myopathy, muscle mass reduction (atrophy).

Dermatological reactions: delayed wound healing, petechiae, ecchymosis, skin thinning, hyper- or hypopigmentation, steroid acne, stretch marks, susceptibility to pyoderma and candidiasis.

Allergic reactions: generalized (including skin rash, itching, anaphylactic shock) and when used topically.

Effects associated with immunosuppressive action: development or exacerbation of infection (the appearance of this side effect is promoted by coadministration of immunosuppressive drugs and vaccination).

Local reactions: in parenteral – tissue necrosis.

When applied externally: rarely – itching, redness, burning, dryness, folliculitis, acne, hypopigmentation, perioral dermatitis, allergic dermatitis, skin maceration, secondary infection, skin atrophy, stripping, miliaria. Systemic side effects characteristic of SCS may develop with prolonged use or application to large areas of skin.

Soldesam contraindications

For short-term use for health reasons – hypersensitivity to Soldesam.

For intra-articular injections and injections directly into the lesion: Prior arthroplasty, abnormal bleeding (endogenous or caused by use of anticoagulants), intra-articular fracture, infectious (sepsis) joint inflammation and periarticular infections (including a history), and general infectious disease, marked concurrent joint osteoporosis, No signs of joint inflammation (“dry” joint, such as osteoarthritis without synovitis), severe bone destruction and joint deformity (severe narrowing of joint space, ankylosis), joint instability due to arthritis, aseptic necrosis at epiphysis of bones that form the joint.

For external use: bacterial, viral, fungal skin diseases, tuberculosis, cutaneous manifestations of syphilis, skin tumors, aftertreatment, skin integrity disorders (ulcers, wounds), childhood (under 2 years, with itching in the anal area – under 12 years), rosacea, acne vulgaris, perioral dermatitis.

For use in ophthalmology: bacterial, viral, fungal eye diseases, tuberculosis eye lesions, falcification of the eye epithelium, acute form of purulent eye infection in the absence of specific therapy, corneal diseases in combination with epithelial defects, trachoma, glaucoma.

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